Multidrug Resistance Proteins (MRPs) and Cancer Therapy
نویسندگان
چکیده
منابع مشابه
Mammalian multidrug-resistance proteins (MRPs).
Subfamily C of the human ABC (ATP-binding cassette) superfamily contains nine proteins that are often referred to as the MRPs (multidrug-resistance proteins). The 'short' MRP/ABCC transporters (MRP4, MRP5, MRP8 and ABCC12) have a typical ABC structure with four domains comprising two membrane-spanning domains (MSD1 and MSD2) each followed by a nucleotide-binding domain (NBD1 and NBD2). The 'lon...
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ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2015
ISSN: 1550-7416
DOI: 10.1208/s12248-015-9757-1